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Semaglutide was the most cost-effective treatment compared to exenatide, dulaglutide, liraglutide, or no treatment in short-term analyses (approximately one and a half years) that assessed quality-adjusted life years and incremental cost-effectiveness ratios [135,136,137,138,139,140,141,142,143,144]

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In the case of rAmy:AMY 3 R:G s , the histidine residues predicted as tautomer were: H226 (CTR), H41, H357 (G), 54, 183, 311 (G)

Similar results were also observed in the BLM model of aged mice (Fig